A Soft Skin Adhesive (SSA) Patch for Extended Release of Pirfenidone in Burn Wounds

As much as half or more of deep partial-thickness burn wounds develop hypertrophic scarring and contracture. Once formed, treatments are only minimally effective. Pirfenidone (Pf), indicated for treatment idiopathic pulmonary fibrosis, is an anti-inflammatory anti-fibrotic small molecule that potentially can be repurposed a preventative against in wounds. We present drug-in-matrix patch with soft skin adhesive (SSA) wound-contacting layer multi-day drug delivery Pf into at the point injury. Our construction consists SSA (Liveo™ MG7-9850, Dupont, Wilmington, DE, USA) wound fixation, acrylic co-polymer matrix (DURO-TAK 87-2852, Henkel, Düsseldorf, Germany) (Pf) reservoir, outermost protective polyurethane backing. By employing design, loaded high 2 mg/cm2. Compared to preparations commercial films, adding markedly reduces stripping observed under scanning electron microscopy (SEM). Moreover, addition varying thicknesses did not interfere vitro release kinetics permeation ex vivo porcine skin. The easily applied onto removed from on Duroc pigs. Continuous dosing by patches (>200 μg/cm2/day) reduced proinflammatory biomarkers produced manual laboratory-scale process showed excellent stability, maintaining intact physical properties biological activity up one year long-term (25 °C 60% RH) 6 months accelerated (40 75% test conditions. To manufacture our safe-and-extended-release patch, we scale-up processes using machine-driven automated roll-to-roll pilot scale coater.